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KMID : 0882420120830030337
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Korean Journal of Medicine
2012 Volume.83 No. 3 p.337 ~ p.341
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A Case of Multiple Tuberculosis Associated with Infliximab Therapy in Crohn’s Disease
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Kim Hee-Wook
Jang Sung-Ill
Kim Bun
Youn Young-Hoon
Byun Min-Kwang
Park Hyo-Jin
Lee Sang-In
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Abstract
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Infliximab, a tumor necrosis factor-α (TNF-α) inhibitor, has been approved for the treatment of a variety of inflammatory illnesses, including Crohn’s disease. However, infliximab can increase the risk of reactivation of latent tuberculosis (Tbc) infection by affecting host immune responses. Therefore, a screening test should be performed before the initiation of infliximab therapy, and patients with evidence of latent infection should be treated with prophylactic anti-Tbc therapy. Here, we report a case of multifocal disseminated tuberculosis after treatment with infliximab in a patient diagnosed with Crohn’s disease who had no past history of Tbc and showed a negative screening test.
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KEYWORD
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Infliximab, Tuberculosis, Tumor necrosis factor-α
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